Beta-agonists can sometimes increase heart rate or have other cardiovascular effects, particularly when used in high doses or if hypokalemia is present. the nervous system is similar to the endocrine system in that both work through chemical messengers to affect physiological responses. The client is not allowed to take anything orally following complications of abdominal surgery and is receiving high-glucose total parenteral nutrition via a central IV line. which endocrine gland also acts as an exocrine gland? Study with Quizlet and memorize flashcards containing terms like Which of the following carbohydrates is the end product of photosynthesis? Safety and efficacy have not been established. Carvedilol is a P-glycoprotein (P-gp) inhibitor and maraviroc is a P-gp substrate. Cabozantinib: (Minor) Monitor for an increase in carvedilol-related adverse reactions if coadministration with cabozantinib is necessary. Select all that apply. The applesauce should not be warm because it could affect the modified-release properties. Tirzepatide: (Moderate) Increased frequency of blood glucose monitoring may be required when a beta blocker is given with antidiabetic agents. (Moderate) Monitor for an increase in atorvastatin-related adverse reactions, including myopathy and rhabdomyolysis, if coadministration with carvedilol is necessary. Beta-blockers also exert complex actions on the body's ability to regulate blood glucose. Additionally, because of the potential to cause coronary vasospasm, ergot alkaloids could antagonize the therapeutic effects of anti-anginal agents including beta-blockers; clinicians should keep in mind that ergot alkaloids are contraindicated for use in patients with coronary heart disease or hypertension. this is an example of which feedback mechanism? Her total energy intake was 2,000 calories. Bupropion; Naltrexone: (Minor) Monitor for an increased incidence of carvedilol-related adverse effects if bupropion and carvedilol are used concomitantly. The effects of the syndrome of inappropriate antidiuretic hormone (SIADH) secretion include which solute? Loperamide is a P-gp substrate and carvedilol is a P-gp inhibitor. Tamsulosin: (Minor) Tamsulosin did not potentiate the hypotensive effects of atenolol. Carvedilol is a P-glycoprotein (P-gp) inhibitor and dolutegravir is a P-gp substrate in vitro. Pazopanib: (Moderate) Altered concentrations of pazopanib and/or carvedilol may occur during coadministration. C) monosaccharides. Use caution if concomitant use is necessary and monitor for increased side effects. Give glucagon by injection or a nasal spray; Call 911 or emergency services in your area for immediate treatment if glucagon isn't on hand, you don't know how to use it or the person isn't responding; Hypoglycemia unawareness. Coadministration with another P-gp inhibitor increased rifaximin overall exposure by 124-fold. Rifaximin: (Moderate) Monitor for an increase in rifaximin-related adverse reactions if coadministration with carvedilol is necessary. Patients should be monitored for excess beta-blockade. Teniposide: (Moderate) Increased concentrations of teniposide may occur if it is coadministered with carvedilol; exercise caution. a. Baclofen: (Moderate) Baclofen has been associated with hypotension. Carvedilol is partially metabolized by P-glycoprotein (P-gp) and simeprevir inhibits P-gp. Beta-blocker treatment can be initiated in patients receiving stable doses of ponesimod. The antihypertensive effect of beta-blockers may be diminished by NSAIDs. Alemtuzumab: (Moderate) Alemtuzumab may cause hypotension. Study with Quizlet and memorize flashcards containing terms like "1. Blood Sugar Amprenavir, the active metabolite of fosamprenavir, is a P-gp inducer and substrate. Prep U Q7: Diabetes Beta-blockers may be continued during general anesthesia as long as the patient is monitored for cardiac depressant and hypotensive effects. Tetracaine: (Moderate) Local anesthetics may cause additive hypotension in combination with antihypertensive agents. Some beta-blockers, particularly non-selective beta-blockers such as propranolol, have been noted to potentiate insulin-induced hypoglycemia and a delay in recovery of blood glucose to normal levels. Quizlet Concomitant use may increase atorvastatin exposure. d) it increases water retention by the kidneys, what is the function of antidiuretic hormone? Both ceritinib and carvedilol can cause bradycardia. While beta-blockers may have negative effects on glycemic control, they reduce the risk of cardiovascular disease and stroke in patients with diabetes and their use should not be avoided in patients with compelling indications for beta-blocker therapy when no other contraindications are present. At what time should she receive her prescribed dose of NPH insulin? Beta-blockers also exert complex actions on the body's ability to regulate blood glucose. Isosorbide Dinitrate, ISDN: (Moderate) Nitroglycerin can cause hypotension. At what time should she receive her prescribed dose of NPH insulin? Dihydroergotamine: (Moderate) Concurrent use of beta-blockers and ergot alkaloids should be approached with caution. Similar to how some fat is required in a healthy diet, some fat is needed on the body to protect organs and regulate body temperature. Peripheral vasodilation may occur after use of bupivacaine. Some beta-blockers, particularly non-selective beta-blockers such as propranolol, have been noted to potentiate insulin-induced hypoglycemia and a delay in recovery of blood glucose to normal levels. secretions from which glands alter the metabolism of their target cells? Hydralazine; Isosorbide Dinitrate, ISDN: (Moderate) Nitroglycerin can cause hypotension. If the antihypertensive cannot be stopped, patients should not receive amifostine. Intravenous Lipid Emulsions: (Moderate) High doses of fish oil supplements may produce a blood pressure lowering effect It is possible that additive reductions in blood pressure may be seen when fish oils are used in a patient already taking antihypertensive agents. Typically, dosages are titrated at approximately 2 week intervals as tolerated to a maximum of about 0.8 mg/kg/day (Max: 50 mg/day). Decreases in the AUC (27%) and Cmax (43%) are observed when extended-release carvedilol is administered in the fasted state compared to administration after a standard meal. Coadministration with another P-gp inhibitor increased berotralstat exposure by 69%. the gland that is attached to the roof of the third ventricle of the brain, beneath the posterior end of the corpus callosum, is the _________________ gland. a) endocrine b) exocrine c) apocrine d) sebaceous. The nurse is caring for a client taking bromocriptine (Cycloset). (Moderate) Concurrent administration of carvedilol with dasabuvir; ombitasvir; paritaprevir; ritonavir or ombitasvir; paritaprevir; ritonavir may result in elevated plasma concentrations of carvedilol and the components of the hepatitis C regimen. Some beta-blockers, particularly non-selective beta-blockers such as propranolol, have been noted to potentiate insulin-induced hypoglycemia and a delay in recovery of blood glucose to normal levels. Acetaminophen; Aspirin, ASA; Caffeine: (Moderate) Concurrent use of beta-blockers with aspirin and other salicylates may result in loss of antihypertensive activity due to inhibition of renal prostaglandins and thus, salt and water retention and decreased renal blood flow. Beta-blockers also exert complex actions on the body's ability to regulate blood glucose. Blood concentrations of local anesthetics achieved after therapeutic doses are associated with minimal change in peripheral vascular resistance. Concurrent use may increase berotralstat exposure and the risk of adverse effects. This condition is a complex disordered metabolic state characterized by hyperglycemia, ketoacidosis, and ketonuria. Increase dosage to 20, 40, and then 80 mg PO once daily over intervals of at least 2 weeks as tolerated. Coadministration of drugs that slow heart rate increases the risk for bradycardia. If used concurrently, close clinical monitoring with appropriate beta-blocker dose reductions are advise. Coreg (carvedilol) dose, indications, adverse effects Other symptoms, like headache, dizziness, nervousness, mood changes, or hunger are not blunted. The gastrointestinal track breaks proteins down into amino acids ______________. Acetaminophen; Aspirin; Diphenhydramine: (Moderate) Concurrent use of beta-blockers with aspirin and other salicylates may result in loss of antihypertensive activity due to inhibition of renal prostaglandins and thus, salt and water retention and decreased renal blood flow. Reduce dose for bradycardia (heart rate less than 55 beats per minute). Which of the following statements about protein is correct? Samantha, who has a shellfish allergy, eats a serving of clams. While beta-blockers may have negative effects on glycemic control, they reduce the risk of cardiovascular disease and stroke in patients with diabetes and their use should not be avoided in patients with compelling indications for beta-blocker therapy when no other contraindications are present. A nurse should take what steps prior to administering insulin glargine (Lantus) to a client? A low-calorie cake would most likely be baked with ____. Insulins: (Moderate) Increased frequency of blood glucose monitoring may be required when a beta blocker is given with antidiabetic agents. In addition, dasabuvir, ombitasvir, paritaprevir, and ritonavir are all P-gp substrates. The_______ is the group that varies for each amino acids, Of the 20 amino acids in the body 9 are considered ______ which means the body does not produce enough to meet needs and they are therefore must be obtained from the diet. 1) hormone receptor binding activates G-protein. Carvedilol is metabolized primarily by CYP2D6 and CYP2C9; rifampin is a known CYP450 hepatic enzyme inducer. select all that apply. If carvedilol is discontinued, wait at least 3 to 5 half-lives of carvedilol before increasing the dose of talazoparib to the prior dose used before carvedilol therapy. Use of a beta-blocker in patients with preserved ejection fraction heart failure (HFpEF) and hypertension is reasonable to control blood pressure. Lurasidone: (Moderate) Due to the antagonism of lurasidone at alpha-1 adrenergic receptors, the drug may enhance the hypotensive effects of alpha-blockers and other antihypertensive agents. Prazosin: (Moderate) Orthostatic hypotension may be more likely if beta-blockers are coadministered with alpha-blockers. Bismuth Subsalicylate; Metronidazole; Tetracycline: (Moderate) Concurrent use of beta-blockers with bismuth subsalicylate and other salicylates may result in loss of antihypertensive activity due to inhibition of renal prostaglandins and thus, salt and water retention and decreased renal blood flow. c. It should supply enough nitrogen to make nonessential amino acids. He weighs 260 pounds, of which 220 pounds are lean body mass. Ivacaftor is an inhibitor of CYP3A, P-glycoprotein (Pgp) and a weak inhibitor of CYP2C9; carvedilol is partially metabolized by CYP3A, CYP2C9 and is a substrate of Pgp. and more. the gland that secretes several hormones that stimulate the development of lymphatic organs and regulate the development and activity of T cells is the __________________. Study with Quizlet and memorize flashcards containing terms like The effects of the syndrome of inappropriate antidiuretic hormone (SIADH) secretion include which solute? c) to stimulate mitosis and cell differentiation, b) to stimulate contraction of the smooth muscle of the uterus. Remifentanil: (Moderate) The risk of significant hypotension and/or bradycardia during therapy with remifentanil may be increased in patients receiving beta-blockers or calcium-channel blockers due to additive hypotensive effects. The nurse realizes the client is experiencing symptoms of hypoglycemia Since beta blockers inhibit the release of catecholamines, these medications may hide symptoms of hypoglycemia such as tremor, tachycardia, and blood pressure changes. Titrate milrinone dosage according to hemodynamic response. A savvy nutrition consumer looking for a fiber cereal by checking the labels would put back a product with _____ listed as the first ingredient. Many health organizations suggest substituting beans and vegetables for animal protein at dinner. Carvedilol is a CYP2C9 substrate and apalutamide is a weak CYP2C9 inducer. These effects can be used to therapeutic advantage, but dosage adjustments may be necessary. All beta-blockers, including beta1-selective agents, should be used with caution in these patients, particularly with high-dose therapy. Bupivacaine Liposomal: (Moderate) Local anesthetics may cause additive hypotension in combination with antihypertensive agents. When the person asks why this is necessary, the professional states that retinopathy develops in patients with diabetes mellitus because of what reason? Other symptoms, like headache, dizziness, nervousness, mood changes, or hunger are not blunted. Carvedilol lowers standing blood pressure more than supine; orthostatic hypotension may occur. Carvedilol and vemurafenib are both substrates and inhibitors of P-glycoprotein (P-gp). a. CoQ10 use in combination with antihypertensive agents may lead to additional reductions in blood pressure in some individuals. Quizlet If someone lacked protein in their diet, they would experience _____. what is one difference between hormones of the endocrine system and neurotransmitters of the nervous system? Sodium retention and water loss c. Sodium dilution and water retention d. Sodium dilution and water loss, Which patient would the healthcare professional assess for elevated Other symptoms, like headache, dizziness, nervousness, mood changes, or hunger are not blunted. Maintain patients on lower doses if higher doses are not tolerated. The final suspension volume is 30 ml. Insulin Glargine; Lixisenatide: (Moderate) Increased frequency of blood glucose monitoring may be required when a beta blocker is given with antidiabetic agents. Hyperglycemia has been reported as well and is possibly due to beta-2 receptor blockade in the beta cells of the pancreas. The germ and bran are the key parts of a grain that make whole grains higher in fiber, protein, and nutrients. Concomitant use is likely to lead to increased concentrations of carvedilol; exposure to temsirolimus may also increase. What is her protein RDA if she weighs 148 pounds and is in good health? Ben sees that MyPlate recommends he consume 8 ounces of grains daily based on his energy needs; this means that at least three ounces should come from whole grain sources. Co-administration of ivacaftor with CYP3A, CYP2C9, and Pgp substrates,such as carvedilol, can theoretically increase carvedilol exposure leading to increased or prolonged therapeutic effects and adverse events; however, the clinical impact of this has not yet been determined. A healthcare professional is palpating the neck of a person diagnosed with Graves' disease. PTH is secreted in response to low levels of the mineral __________________. Concomitant use warrants caution due to the potential for increased side effects. Terbinafine: (Minor) Inhibitors of the hepatic CYP450 isozyme CYP 2D6, including terbinafine, may inhibit the hepatic oxidative metabolism of carvedilol. Maintain patients on lower doses if higher doses are not tolerated. Carvedilol is a CYP2C9 substrate. Blood Sugar Which of following ongoing assessments should the nurse perform when caring for this patient? After the first fingolimod dose, overnight monitoring with continuous ECG in a medical facility is advised for patients who cannot stop taking drugs that slow the heart rate or atrioventricular conduction. Carvedilol is a CYP2C9 substrate and escitalopram is a CYP2C9 inhibitor. _________ provide the largest portion of American's protein intake. Add 10 mL Ora-Sweet SF and 15 mL Oral-Plus to the mixture, then cap the bottle and shake vigorously for 30 seconds for adequate mixing. When used together, AV block can occur. which would you expect to see in a urinalysis of an untreated diabetic? Beta-blockers also exert complex actions on the body's ability to regulate blood glucose. With the exception of dizziness in hypertensive patients (8.8% for elderly vs. 6% for younger patients), no overall differences in the safety or effectiveness of immediate-release carvedilol were seen. About _____ of the body's energy needs at rest is supplied by fat. T/F Clients with type 2 diabetes have nonfunctioning beta pancreatic cells. Saturated fats are fats that have room for more hydrogen bonds. Thus, patients receiving antihypertensive agents may experience additive hypotensive effects. An A1C result below 5.7 is considered normal; 5.7 to 6.4 is prediabetic; 6.5 or above suggests diabetes. Some beta-blockers, particularly non-selective beta-blockers such as propranolol, have been noted to potentiate insulin-induced hypoglycemia and a delay in recovery of blood glucose to normal levels. Increased carvedilol exposure is possible. Study with Quizlet and memorize flashcards containing terms like Glucose is the body's primary energy nutrient and is found in lean meats and fish. It has been proposed that lipophilic beta-blockers (e.g., carvedilol) are more likely to be associated with CNS effects than hydrophilic drugs; however, this theory has been debated based on clinical experience with beta-blockers. Use caution if concomitant use is necessary and monitor for increased side effects. Concurrent use with baclofen and antihypertensive agents may result in additive hypotension. Coadministration of bupropion and carvedilol may result in increased plasma concentrations of carvedilol. What structural component of amino acids differentiates them from one another? Doxazosin: (Moderate) Orthostatic hypotension may be more likely if beta-blockers are coadministered with alpha-blockers. Higher blood concentrations of local anesthetics may occur due to inadvertent intravascular administration or repeated doses. select all that apply. as a group, the pituitary hormones that stimulate the ovaries and testes are known as what? In severe cases, when a person is vomiting or not able to cooperate, coordinate swallowing, or fully conscious, glucagon should be used to treat hypoglycemia. If these medications are administered together, monitor for tenofovir-associated adverse reactions. Hyperglycemia has been reported as well and is possibly due to beta-2 receptor blockade in the beta cells of the pancreas. Monitor ECG and blood pressure if verapamil is coadministered with carvedilol. Simvastatin is a P-gp substrate; carvedilol is a P-gp inhibitor. Carvedilol is a P-glycoprotein (P-gp) inhibitor and docetaxel is a P-gp substrate. Intermittent hemodialysisDue to its high degree of plasma protein-binding, carvedilol is not likely to be significantly removed by hemodialysis. Thiazolidinediones: (Moderate) Increased frequency of blood glucose monitoring may be required when a beta blocker is given with antidiabetic agents. Hypoglycaemia which substances are secreted by pancreatic islet cells? Monitoring of lidocaine concentrations is recommended during concomitant therapy with beta-blockers. Cimetidine inhibits several hepatic cytochrome isozymes, including CYP2D6 and has been shown to increase carvedilol steady-state area under the plasma-concentration time curve (AUC) by 30%. the inner core of the adrenal gland is called the adrenal ________________. Alogliptin; Metformin: (Moderate) Increased frequency of blood glucose monitoring may be required when a beta blocker is given with antidiabetic agents. Dexmedetomidine can produce bradycardia or AV block and should be used cautiously in patients who are receiving antihypertensive drugs that lower the heart rate such as beta-blockers. which adrenal cortical hormones are responsible for the growth of pubic and axillary hair during puberty? A nurse is preparing to administer a rapid-acting insulin. The reduction of effects may be especially evident when a patient goes from a hypothyroid to a euthyroid state or when excessive amounts of thyroid hormone is given to the patient. Patients should be instructed to rise slowly from a sitting position, and to report syncope or changes in blood pressure or heart rate to their health care provider. Which two foods have a similar effect on blood lipids? Artemether; Lumefantrine: (Moderate) Lumefantrine is an inhibitor and carvedilol is a substrate of the CYP2D6 isoenzyme; therefore, coadministration may lead to increased carvedilol concentrations. Beta-blockers also exert complex actions on the body's ability to regulate blood glucose. Use of a beta-blocker in patients with preserved ejection fraction heart failure (HFpEF) and hypertension is reasonable to control blood pressure. Close monitoring following the initial dose and up-titration of carvedilol is prudent in patients with advanced heart failure who are referred for cardiac transplantation. Chlorthalidone; Clonidine: (Moderate) Monitor heart rate in patients receiving concomitant clonidine and agents known to affect sinus node function or AV nodal conduction (e.g., beta-blockers). Study with Quizlet and memorize flashcards containing terms like The effects of the syndrome of inappropriate antidiuretic hormone (SIADH) secretion include which solute? When you have diabetes, your blood sugar (aka blood glucose) levels may be consistently high. Because the first-pass metabolism is stereoselective, plasma concentrations of R(+)-carvedilol are about 2 to 3 times higher than S(-)-carvedilol after administration to healthy subjects. If concurrent use of lurasidone and antihypertensive agents is necessary, patients should be counseled on measures to prevent orthostatic hypotension, such as sitting on the edge of the bed for several minutes prior to standing in the morning and rising slowly from a seated position. Coadministration of dronedarone with a single dose of propranolol and multiple doses of metoprolol increased propranolol and metoprolol exposure by 1.3- and 1.6-fold, respectively. Coadministration is contraindicated in patients with renal or hepatic impairment because colchicine accumulation may be greater in these populations. Some people may lose the ability to sense that their blood sugar levels are getting low. The use of an evidence-based beta blocker is recommended for patients with HFrEF NHYA class I to IV. Which intervention should the nurse perform before administering each insulin dose? A selective beta-blocker may be preferred in patients with diabetes mellitus, if appropriate for the patient's condition. any agent, such as a hormone or drug, that opposes another is acting as an ___________________. The initial FDA-approved dosage is 6.25 mg PO twice daily, taken with food, for the first 3 to 10 days. John's doctor wants him to change his eating habits to lower his blood cholesterol. a. which glands secrete their product by way of a duct directly onto an epithelial surface? Ceritinib: (Major) Avoid concomitant use of ceritinib with carvedilol if possible due to the risk of additive bradycardia. It would result in high blood glucose and no effect on ACTH or TSH. Patients should be instructed to rise slowly from a sitting position, and to report syncope or changes in blood pressure or heart rate to their health care provider. which hormone stimulates the deposition of calcium in bones? Drugs that reduce catecholamine uptake or deplete catecholamine stores, such as carvedilol, may interfere with iobenguane I-131 uptake into cells and interfere with dosimetry calculations resulting in altered iobenguane I-131 efficacy. Beta-blockers may be continued during general anesthesia as long as the patient is monitored for cardiac depressant and hypotensive effects. Since beta blockers inhibit the release of catecholamines, these medications may hide symptoms of hypoglycemia such as tremor, tachycardia, and blood pressure changes. Monitor clinical response during coadministration; adjustment of nifedipine dosage may be needed during concurrent beta-blocker therapy. what effect does thyroid hormone have on the body's metabolic rate? Carvedilol is a P-glycoprotein (P-gp) inhibitor and dexamethasone is a P-gp substrate. This effect is of particular concern in the setting of acute myocardial infarction, unstable angina, or other acute hemodynamic compromise. Ivacaftor: (Moderate) Increased monitoring is recommended if ivacaftor is administered concurrently with CYP2C9 substrates, such as carvedilol. Venetoclax: (Major) Reduce the dose of venetoclax by at least 50% and monitor for venetoclax toxicity (e.g., hematologic toxicity, GI toxicity, and tumor lysis syndrome) if coadministered with carvedilol due to the potential for increased venetoclax exposure. The nurse explains to the patient that type 2 diabetes differs from type 1 diabetes primarily in that with type 2 diabetes a. the pt is totally dependent on an outside source of insulin b. there is a which are peptide hormones? Some people may lose the ability to sense that their blood sugar levels are getting low. Systemic drug interactions with the urethral suppository (MUSE) or alprostadil intracavernous injection are unlikely in most patients because low or undetectable amounts of the drug are found in the peripheral venous circulation following administration. Therapy should be continued during and after hospitalization for all patients with no contraindications for use. Patients with cirrhotic hepatic disease may have significantly higher concentrations of carvedilol (approximately 47 fold) compared to healthy patients. c. can provide an adequate assortment of amino acids. Amiodarone: (Moderate) Monitor for signs of bradycardia or heart block if coadministration of carvedilol with amiodarone is necessary. Selective beta-blockers, such as atenolol or metoprolol, do not appear to potentiate insulin-induced hypoglycemia. Estradiol Cypionate; Medroxyprogesterone: (Minor) Estrogens can induce fluid retention and may increase blood pressure in some patients; patients who are receiving antihypertensive agents concurrently with hormonal contraceptives should be monitored for antihypertensive effectiveness. Diabetes _____________________ hypothyroidism is due to thyroid hyposecretion from birth. Patients should be informed about measures to prevent orthostatic hypotension, such as sitting on the edge of the bed for several minutes prior to standing in the morning, or rising slowly from a seated position. Blood concentrations of local anesthetics achieved after therapeutic doses are associated with minimal change in peripheral vascular resistance. Although improved heart failure outcomes have not been demonstrated in one randomized placebo-controlled clinical trial, limited clinical trials have shown improved left ventricular function, symptoms, and/or functional class in pediatric patients with heart failure including patients with dilated cardiomyopathy. Study with Quizlet and memorize flashcards containing terms like b) amino acids, diabetes mellitus, a) adrenal cortex + b) ovary + c) testes and more. Carvedilol is a P-glycoprotein (P-gp) inhibitor and budesonide is a P-gp substrate. In this study, an initial test dose of 6.25 mg PO or 12.5 mg atenolol PO was administered to patients with NYHA Class III/IV heart failure referred for cardiac transplantation. Which of the following nutrients does not promote growth and development as its primary function? which of the following is a hypoglycemic hormone? Beta-blockers lower the threshold for and increase the severity of contrast reactions and reduce the responsiveness of treatment of hypersensitivity reactions with epinephrine. Denaturation is the first step to breaking down a protein for digestion. In addition, cocaine can reduce the therapeutic effects of beta-blockers. Beta-blockers also exert complex actions on the body's ability to regulate blood glucose. D) Calories., Which monosaccharide is the preferred Increase the dose after 2 weeks as tolerated to 6.25, 12.5, 25, and then 50 mg PO twice daily. How can the nurse best assess the client's glycemic control since beginning treatment? Asciminib: (Moderate) Monitor for signs of bradycardia or heart block if coadministration of carvedilol with asciminib 200 mg twice daily is necessary. Blood Sugar Additionally, because of the potential to cause coronary vasospasm, these ergot alkaloids could antagonize the therapeutic effects of anti-anginal agents including beta-blockers; clinicians should keep in mind that ergot alkaloids are contraindicated for use in patients with coronary heart disease or hypertension. while both the endocrine and nervous systems are involved with communication, they differ in their mechanisms. Coadministration may increase serum concentrations of carvedilol. Taking these medications together may increase the plasma concentrations of both drugs, potentially resulting in adverse events. Apomorphine: (Moderate) Use of beta blockers and apomorphine together can increase the hypotensive effects of apomorphine. b. Ann has a healthy amount of good cholesterol. A. c. 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