View abstract. [Efficacy and safety of bivalos therapy for postmenopausal osteoporosis. N.Engl.J.Med. 2006;21(4):536-542. Rheumatology (Oxford). (Accessed 10 October 2006). I have been treated with bisphosphanates, forteo, prolia and I had 11 non-traumatic spontaneous vertebral compression fractures during treatment. View abstract. Strontium and calcium metabolism. Instant breakfast drink, various flavors and brands, powder prepared with water, 8 ounces 105-250 mg per serving. Methods: Custom-made MDO devices were placed on 20 New Zealand White rabbits. I was told by the endocrinologist who I went to for osteoporosis that AlgaeCal is no better than taking calcium and vitamin D. I am reading the book "Strong Women, Strong Bones" and I highly recommend it. Pelletier JP, Roubille C, Raynauld JP, et al. Roque, I. Figuls, Martinez-Zapata, M. J., Scott-Brown, M., and Alonso-Coello, P. Radioisotopes for metastatic bone pain. 2005;54(9):758-767. Cancer that has spread to bone and causes pain. View abstract. Aging Clin.Exp.Res. Chemical exchange between glass-ionomer restorations and residual carious dentine in permanent molars: an in vivo study. BMC.Musculoskelet.Disord. A., Mohr, D. N., Petterson, T. M., O'Fallon, W. M., and Melton, L. J., III. Hwang, J. S., Chen, J. F., Yang, T. S., Wu, D. J., Tsai, K. S., Ho, C., Wu, C. H., Su, S. L., Wang, C. J., and Tu, S. T. The effects of strontium ranelate in Asian women with postmenopausal osteoporosis. Quintessence.Int. View abstract. These forms are different from the ranelate compound and there have been no studies showing that they are safe or effective. Doctors can prescribe it only for postmenopausal women and for men with severe osteoporosis who cant take other drugs. View abstract. Ann.Rheum.Dis. This is not the same as making new bone. (Accessed 8 August 2006). Acta Biomater. Incidence and mortality of venous thrombosis: a population-based study. 1990;34(3):545-560. Its been interesting what research has shown to date aboutits use for osteoporosis. There were, however, significant increases in both heart attacks and blood clots (including pulmonary embolism) in patients taking strontium ranelate compared to those who were not. Agency for Toxic Substances and Disease Registry. J.Clin.Endocrinol.Metab 2005;90(5):2816-2822. 2013 Feb;98(2):592-601. doi: 10.1210/jc.2012-3048. Am J Med. Any feedback to help me through this maze will be highly appreciated. Eur.J.Nucl.Med. Zinner, D. D., Duany, L. F., and Lutz, H. J. Dr. Lanis No-Nonsense Bone Health Guide. Scaglione M, Fabbri L, Casella F, Guido G. Strontium ranelate as an adjuvant for fracture healing: clinical, radiological, and ultrasound findings in a randomized controlled study on wrist fractures. View abstract. [2] Royal Osteoporosis Society. Posted: 09/28/19;Revised: 09/25/20. Manicourt, D. H., Azria, M., Mindeholm, L., Thonar, E. J., and Devogelaer, J. P. Oral salmon calcitonin reduces Lequesne's algofunctional index scores and decreases urinary and serum levels of biomarkers of joint metabolism in knee osteoarthritis. Sr-89 has been used as a form of treatment to manage pain resulting from bone pain due to cancer. A., Weiss, S. R., Broll, J., Minne, H. W., Quan, H., Bell, N. H., Rodriguez-Portales, J., Downs, R. W., Jr., Dequeker, J., and Favus, M. Effect of oral alendronate on bone mineral density and the incidence of fractures in postmenopausal osteoporosis. Dijkgraaf-Ten Bolscher M, Netelenbos JC, Barto R, van der Vijgh WJ. According to Cancer Research UK, If there are cancer cells in more than one area of bone, radioactive strontium can work well to treat those areas and reduce pain. (11). Please note the date of the last review on all articles. Adami, S. Protelos: nonvertebral and hip antifracture efficacy in postmenopausal osteoporosis. Blotman, F., Maheu, E., Wulwik, A., Caspard, H., and Lopez, A. Efficacy and safety of avocado/soybean unsaponifiables in the treatment of symptomatic osteoarthritis of the knee and hip. 1998-2023 Mayo Foundation for Medical Education and Research. American Bone Health4208 Six Forks RoadSuite 1000Raleigh, NC 27609. A double-blind, randomized placebo-controlled trial published in The Journal of Clinical Endocrinology and Metabolism looked at the effects of Sr on 261 men with primary osteoporosis. Strontium as a marker for intestinal calcium absorption: the stimulatory effect of calcitriol. You can buy different forms of it, such as strontium citrate, in supplements at supermarkets and health food stores. Rheumatol.Int. McClung, M. R., Geusens, P., Miller, P. D., Zippel, H., Bensen, W. G., Roux, C., Adami, S., Fogelman, I., Diamond, T., Eastell, R., Meunier, P. J., and Reginster, J. Y. You do not know the effectiveness of the supplements. View abstract. Scientific studies have shown that Sr may have positive effects on bone diseases like osteoporosis, bone cancer, prostate cancer, tooth sensitivity and tooth decay. J.Clin.Periodontol. Strontium ranelate has never been approved in the U.S. View abstract. Afflitto, J., Schmid, R., Esposito, A., Toddywala, R., and Gaffar, A. Fluoride availability in human saliva after dentifrice use: correlation with anticaries effects in rats. View abstract. Maintenance of antifracture efficacy over 10 years with strontium ranelate in postmenopausal osteoporosis. 2013 Feb;72(2):179-86. doi: 10.1136/annrheumdis-2012-202231. Seeman, E., Devogelaer, J. P., Lorenc, R., Spector, T., Brixen, K., Balogh, A., Stucki, G., and Reginster, J. Y. Strontium ranelate reduces the risk of vertebral fractures in patients with osteopenia. View abstract. In osteoporotic women treated with strontium ranelate, strontium is located in bone formed during treatment with a maintained degree of mineralization. Sr can be found in Group 2 of the periodic table. View abstract. Complete your request online or contact us by phone. [No authors listed]. J.Dent.Res. J Periodontol. View abstract. Strontium citrate and strontium chloride are supplements and are not tested or regulated by the Food and Drug Administrations (FDA). According to the Michigan Health website: Compared with children with fewer cavities, enamel samples from children with high numbers of caries have been found to contain significantly less strontium. All rights reserved. Its not an idea that is super-new either. (7,8), There have been more studies that show the positive effects of strontium ranelate on osteoporosis and bone fractures. Type: Natural Calcium & Magnesium Supplement. Strontium Boost is supposed to have no side effects at all. Arthritis Rheum. View abstract. J.Dent.Res. Evaluation of symptomatic slow-acting drugs in osteoarthritis using the GRADE system. The naturally occurring form is made up of four stable isotopes: Sr-88 (82.6 percent), Sr-86 (9.9 percent), Sr-87 (7.0 percent), and Sr-84 (0.56 percent). Strontium ranelate increases cartilage matrix formation. 2012;23(1):295-303. doi: 10.1007/s00198-011-1547-8. Clin Chem 1999;45:1548-56. View abstract. ", Human Nutrition, Food & Animal Sciences, University of Hawaii at Manoa: "European strontium drug spurs supplement sales in U.S.", National Osteoporosis Society: Drug treatments for osteoporosis: strontium ranelate (Protelos).. Scand J Rheumatol 2001;30(4):242-247. Antacids are used to decrease stomach acid. As a service to our readers, American Bone Health provides access to our library of archived content. Keep in mind that more research is still needed to confirm its benefits and safety for some of these uses. 2015 Feb;74(2):422-9. doi: 10.1136/annrheumdis-2013-203989. View abstract. Calcif Tissue Int 2000;67:122-7. O'Donnell S, Cranney A, Wells GA, et al. Kanapka, J. Hahn, G. S. Strontium is a potent and selective inhibitor of sensory irritation. View abstract. Given that strontium test results are tied to the strontium ion, citrate is your best option to reap its bone-building benefits. https://www.mayoclinic.org/diseases-conditions/osteoporosis/in-depth/osteoporosis-treatment/art-20046869, https://connect.mayoclinic.org/discussion/reclast-infusion/, https://americanbonehealth.org/bonesense/why-strontium-is-not-good-for-bone-health/. Ann Rheum Dis. View abstract. Hughes, N., Mason, S., Jeffery, P., Welton, H., Tobin, M., O'Shea, C., and Browne, M. A comparative clinical study investigating the efficacy of a test dentifrice containing 8% strontium acetate and 1040 ppm sodium fluoride versus a marketed control dentifrice containing 8% arginine, calcium carbonate, and 1450 ppm sodium monofluorophosphate in reducing dentinal hypersensitivity. View abstract. A 2016 systematic review published in European Urology took a look at several radiopharmaceuticals including Sr-89 for reducing the malignant bone pain from prostate cancer. Can Med Assoc J 1981;125:703-12.. View abstract. It is said to have first been found in the ores of lead mines in Strontian in 1787. View abstract. Ananthraman, J. and Shahani, S. N. Clinical management of dentin hypersensitivity using cathode and anode iontophoresis. It does this in two ways. Natural strontium has a silvery white metallic color with a tint of yellow. Moise H, Chettle DR, Pejovic-Milic A. J.Fam.Pract. N.Engl.J.Med. Perit Dial Int 1998;18:410-4. 1992;19(10):737-740. Protelos European Public Assessment Report, Scientific Discussion. Injecting myself daily. View abstract. View abstract. Strontium 89 therapy for the palliation of pain due to osseous metastases. 1991;13(3):21-25. Br.J.Clin.Pharmacol. This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. View abstract. Medina, J. M., Thomas, A., and Denegar, C. R. Knee osteoarthritis: should your patient opt for hyaluronic acid injection? The Alendronate Phase III Osteoporosis Treatment Study Group. 2014 Aug;53(8):1457-64. doi: 10.1093/rheumatology/keu018. Rintelen, B., Neumann, K., and Leeb, B. F. A meta-analysis of controlled clinical studies with diacerein in the treatment of osteoarthritis. View abstract. Note that the numbers in parentheses (1, 2, etc.) View abstract. 2002;17(3):449-454. Reginster, J. Y., Lecart, M. P., Deroisy, R., and Lousberg, C. Strontium ranelate: a new paradigm in the treatment of osteoporosis. View abstract. Busse, B., Jobke, B., Hahn, M., Priemel, M., Niecke, M., Seitz, S., Zustin, J., Semler, J., and Amling, M. Effects of strontium ranelate administration on bisphosphonate-altered hydroxyapatite: Matrix incorporation of strontium is accompanied by changes in mineralization and microstructure. A special form of strontium called strontium ranelate can increase bone formation and prevent bone loss when used in postmenopausal women with osteoporosis. Bone 2009;45(2):200-206. Gillam, D. G., Newman, H. N., Bulman, J. S., and Davies, E. H. Dentifrice abrasivity and cervical dentinal hypersensitivity. I am actively and urgently in the process of deciding which osteoporosis treatment I want to "pitch" to my doctors. J.Bone Miner.Res. Overview. Dahl SG, Allain P, Marie PJ, et al. [3] Bartl, R. & Bartl, C.The Osteoporosis Manual: Prevention. The forms of strontium available over-the-counter in the U.S. or on the Internet are usually strontium citrate or strontium chloride. Rev Rhum Engl Ed 1997;64(12):825-834. View abstract. View abstract. J.Periodontol. Roux, C., Fechtenbaum, J., Kolta, S., Isaia, G., Andia, J. Contact Dermatitis 2000;42(2):98-100. Effects of strontium ranelate on spinal osteoarthritis progression. https://americanbonehealth.org/bonesense/why-strontium-is-not-good-for-bone-health/ J.Periodontol. Papoiu AD, Valdes-Rodriguez R, Nattkemper LA, Chan YH, Hahn GS, Yosipovitch G. A novel topical formulation containing strontium chloride significantly reduces the intensity and duration of cowhage-induced itch. Positive impact of compliance to strontium ranelate on the risk of nonvertebral osteoporotic fractures. Vlad, S. C., LaValley, M. P., McAlindon, T. E., and Felson, D. T. Glucosamine for pain in osteoarthritis: why do trial results differ? Brand: Algaecal. View abstract. 2011;22(8):2347-2355. Ardissino G, Schmitt CP, Bianchi ML, et al. View abstract. View abstract. View abstract. Reginster, J. Y., Seeman, E., De Vernejoul, M. C., Adami, S., Compston, J., Phenekos, C., Devogelaer, J. P., Curiel, M. D., Sawicki, A., Goemaere, S., Sorensen, O. H., Felsenberg, D., and Meunier, P. J. Strontium ranelate reduces the risk of nonvertebral fractures in postmenopausal women with osteoporosis: Treatment of Peripheral Osteoporosis (TROPOS) study. Cheung, K. M., Lu, W. W., Luk, K. D., Wong, C. T., Chan, D., Shen, J. X., Qiu, G. X., Zheng, Z. M., Li, C. H., Liu, S. L., Chan, W. K., and Leong, J. C. Vertebroplasty by use of a strontium-containing bioactive bone cement. IT was a 9 year nightmare until I started the strontium citrate. Calcium Citrate. Ettinger, B., Black, D. M., Mitlak, B. H., Knickerbocker, R. K., Nickelsen, T., Genant, H. K., Christiansen, C., Delmas, P. D., Zanchetta, J. R., Stakkestad, J., Gluer, C. C., Krueger, K., Cohen, F. J., Eckert, S., Ensrud, K. E., Avioli, L. V., Lips, P., and Cummings, S. R. Reduction of vertebral fracture risk in postmenopausal women with osteoporosis treated with raloxifene: results from a 3-year randomized clinical trial. Bruyre O, Reginster JY, Bellamy N, et al. 2004;86-A(3):538-545. The next big and interesting use of this alkaline earth metal was when it was used in the television production industry, specifically in the cathode ray tubes of color televisions. Rabenda, V. and Reginster, J. Y. Lo, G. H., LaValley, M., McAlindon, T., and Felson, D. T. Intra-articular hyaluronic acid in treatment of knee osteoarthritis: a meta-analysis. Rizzoli, R., Laroche, M., Krieg, M. A., Frieling, I., Thomas, T., Delmas, P., and Felsenberg, D. Strontium ranelate and alendronate have differing effects on distal tibia bone microstructure in women with osteoporosis. Strontium ranelate is comprised of 27.8% strontium and 72.2% ranelic acid. Although Sr-89 is mostly used when there are several painful metastatic sites, its application in earlier stages of the disease is beneficial, and it may decrease progression and the need for external radiotherapy. Further studies are warranted to determine which radiopharmaceutical is preferred for pain relief and/or improvement of survival. Some male hormones include testosterone, nandrolone, oxandrolone, and oxymetholone. Kanis, J. It's also known to increase osteoprotegerin that serves as the decoy for the RANKL and slows the rate of bone resorption. A., Preston, D. F., Wegst, A. V., and Martin, N. L. Treatment of metastatic bone pain with strontium-89. Male hormones (Androgens) might decrease how fast the body gets rid of strontium. I just read this article about strontium. A prescription form of strontiumstrontium ranelate (the ranelate salt), known as Protelos/Osseor was authorized in the European Union to treat severe osteoporosis in women who have been through the menopause and men who are at high risk of broken bones or fracture in the spine and the hip. It is also shown to positively impact the body's usage of testosterone, estrogen, and vitamin D. View abstract. Seeman, E., Vellas, B., Benhamou, C., Aquino, J. P., Semler, J., Kaufman, J. M., Hoszowski, K., Varela, A. R., Fiore, C., Brixen, K., Reginster, J. Y., and Boonen, S. Strontium ranelate reduces the risk of vertebral and nonvertebral fractures in women eighty years of age and older.